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These studies reported subjective pain improvements and mobility increases, though they lacked appropriate placebo controls and blinding

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[23] The primary and minor metabolic pathways respectively are: Primary: L-Phenylalanine L-Tyrosine L-DOPA Dopamine [20] [21] Minor: L-Phenylalanine L-Tyrosine p -Tyramine Dopamine [20] [21] [22] Minor: L-Phenylalanine m -Tyrosine m -Tyramine Dopamine [22] [24] [25] The direct precursor of dopamine, L-DOPA, can be synthesized indirectly from the essential amino acid phenylalanine or directly from the non-essential amino acid tyrosine